PDF Benzer Makaleler

^{Düzce Üniversitesi Tıp Fakültesi 1Çocuk Endokrin Hastalıkları Araştırma Görevlisi, 2Pediatri Araştırma Görevlisi, 3Pediatri Profesörü
*İletişim: oguzhanay1@gmail.com} Neonatal Graves’ disease caused by fetal thyroid gland stimulation is the result of transplacental passage of maternal thyroid-stimulating hormone receptor antibodies in the second trimester of pregnancy. A mother with Graves–Basedow disease had a total thyroidectomy operation three months before a pregnancy; maternal TSH receptor antibody (TRAb) were detected at the sixth month of pregnancy. Antithyroid drug therapy was started to the 34 weeks’ gestational age infant, who was diagnosed with neonatal hyperthyroidism. The condition improved after five weeks of antithyroid therapy. The pathogenesis was believed to be due to transplacental passage of maternal TRAb. This case is presented to highlight the fact that even mothers who have a total throidectomy for Graves’ disease may have infants with rarely seen neonatal Graves’ disease due to the presence of maternal TRAb in the circulation. Anahtar Kelimeler : Graves hastalığı, yenidoğan, anne, total tiroidektomi, TSH reseptör antikoru, hipertiroidizm.