Çocuk Sağlığı ve Hastalıkları Dergisi 2015 , Vol 58 , Num 1
Respiratory tract viruses in infants under 6 months of age during the influenza season
*Eda Karadağ Öncel1, Meral Ciblak2, Burcu Tahire Köksal3, Yasemin Özsürekci1, Zeren Barış3, Selim Badur4, Mehmet Ceyhan5
Hacettepe Üniversitesi Tıp Fakültesi 1Pediatri Uzmanı, 5Pediatri Profesörü, İstanbul Üniversitesi İstanbul Tıp Fakültesi 2Mikrobiyoloji ve Tıbbi Mikrobiyoloji Doçenti, 4 Profesörü, Van Bölge Eğitim ve Araştırma Hastanesi 3Pediatri Uzmanı
*İletişim: dredakaradag@gmail.com
Upper respiratory tract infections (URTIs) are a major cause of morbidity and mortality in children all over the world. Complications and hospitalization are more common in infancy and early childhood. The aim of this study was to determine the frequency of respiratory viruses causing acute respiratory tract symptoms in infants less than 6 months of age during the influenza season. Nasal swabs were obtained from patients from two cities admitted two center with acute upper respiratory tract symptoms suggestive of an influenza-like illness between January and April 2013. Samples were analyzed using multiplex real-time polymerase chain reaction (RT-PCR) to help identify the causative viral pathogen. A total of 126 patients were enrolled in the study. A respiratory virus was detected successfully in 39 (31.7%) children: RSV in 16 (41%) patients, rhinovirus in 7 (17.9%), influenza A (H1N1) in 5 (12.8%), parainfluenza type 3 in 4 (10.3%), coronavirus in 4 (10.3%) (three of them OC63, one of them NL43), and bocavirus, metapneumovirus and H1N1 concomitant with rhinovirus in 1 (2.6%) patient each. A statistically significant younger age was observed in the RT-PCR positive group (11.94±6.58 vs 15.23±5.79, p=0.006). Frequency of the symptoms—fever, cough, nasal congestion, rhinorrhea, respiratory distress, fatigue, irritability and feeding problems—was similar between RT-PCR positive and negative patients. During the study period, 30 (23.8%) patients were hospitalized; 13 (43.3%) of them were in the RT-PCR positive group, while no respiratory viral pathogen was detected in 17 (56.3%) patients; this difference was not statistically significant (p>0.05). The findings of our study indicate that influenza viruses are not frequently seen in infants less than 6 months of age who cannot be vaccinated, with RSV and rhinovirus being the most common causes of acute respiratory tract symptoms in this age group. Anahtar Kelimeler : süt çocuğu, solunum yolu virusları, üst solunum yolu enfeksiyonu.
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