Çocuk Sağlığı ve Hastalıkları Dergisi
2010 , Vol 53 , Num 3
Preeklamptik anne bebeklerinde beyaz küre sayısı ile bronkopulmoner displazi gelişimi ilişkisi
Hacettepe Üniversitesi Tıp Fakültesi 1Pediatri Öğretim Görevlisi, 2Pediatri Profesörü, 3Pediatri Doçenti
Although the etiology is not clear, neonatal neutropenia is frequently seen in
infants of preeclamptic mothers in the first week of life. Bronchopulmonary
dysplasia is a chronic pulmonary morbidity that is associated with fetal and
neonatal inflammation and neutrophil activation. In this study, we aimed to
investigate the relation between absolute neutrophil count and subsequent
development of bronchopulmonary dysplasia in infants of preeclamptic mothers.
Between January 2003 and December 2007, 84 infants of preeclamptic mothers
and 91 controls who were born and admitted to Hacettepe University İhsan
Doğramacı Children’s Hospital Neonatal Intensive Care Unit were included in
the study. Complete blood count including white blood cell and differential
count and peripheral blood smears were noted from hospital records in all
infants. Mean gestational age was 30.2 ± 1.7 weeks in the preeclamptic
group and 30.7 ± 1.8 in the control group, while the mean birth weights
were 1035 ± 177 g and 1042 ± 149 g, respectively. There were statistically
significant differences between the two groups with respect to white blood
cell, absolute neutrophil and platelet counts (p<0.05). There was a positive
correlation between white blood cell count, absolute neutrophil count and
the development of bronchopulmonary dysplasia (white blood cell count odds
ratio [OR]: 3.5, 95% confidence interval [CI]: 1.8-8.8; absolute neutrophil
count OR: 2.6, 95% CI: 1.2-6.3). Neonatal neutropenia, which is frequently
seen in infants of preeclamptic mothers, may prevent the development of
bronchopulmonary dysplasia. Increased white blood cell count may reflect
a risk factor for the development of bronchopulmonary dysplasia but this
should be tested in prospective studies.
Anahtar Kelimeler :
preeklampsi, beyaz küre sayısı, enflamasyon, kronik akciğer
hastalığı, prematürite.