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Hacettepe Üniversitesi Tıp Fakültesi Pediatri Profesörü Our aim was to review the literature examining the effect of prophylactic administration of analgesics on febrile reaction incidence and vaccine responses. MEDLINE, EMBASE and PubMed were searched to identify randomized controlled trials on this subject. Use of prophylactic analgesics (acetaminophen or ibuprofen) may reduce the incidence of febrile reactions in infants aged 2-6 months receiving DTwP (diphtheria-tetanus whole cell pertussis) vaccine. At present, DTwP has been replaced with DTaP (diphtheria-tetanus-acellular pertussis), and fever greater than 39.5°C is uncommon for the other childhood vaccines not containing whole cell pertussis. Administration of prophylactic paracetamol was shown to reduce antibody responses of several vaccines significantly after both primary vaccination (pneumococcal vaccine serotypes, protein D, anti-polyribosyl-ribitol phosphate, anti-diphtheria, anti-tetanus, and anti-pertactin) and boosting (pneumococcal vaccine serotypes apart from 19F, protein D, and anti-tetanus). In conclusion, prophylactic paracetamol should not be given at vaccination, due to no evident benefit for moderate-severe adverse events of vaccines, given the possible reduction in vaccine responses. Anahtar Kelimeler : parasetamol proflaksisi, analjezik, aşı yanıtı, febril reaksiyon.