Çocuk Sağlığı ve Hastalıkları Dergisi 2005 , Vol 48 , Num 1
Return of an ignored cell: mast cells and their defined new roles in hematology-oncology and immunology
Öner Özdemir1, Süreyya Savaşan2
Wayne Devlet Üniversitesi Michigan Çocuk hastanesi (Detroit, ABD) 1Pediatrik İmmunoloji-Hematoloji Araştırma Uzmanı, 2Pediatri Yardımcı Doçenti Özdemir Ö, Savaşan S. (Children’s Hospital of Michigan, Carman Ann Adams Department of Pediatrics, Division of Hematology/Oncology, Wayne State University, Detroit, MI, USA). Return of an ignored cell: mast cells and their defined new roles in hematology-oncology and immunology. Çocuk Sağlığı ve Hastalıkları Dergisi 2005; 48: 85-92.

Recent improvements in mast cell (MC) growth and maintenance in vitro have increased the research efforts. Mast cell maturation, movement across tissues, interactions with surrounding cells and pathogens, and their crucial role in the immune system are better understood. The presence of MC in tumor tissues and their potential role in the disease process in hematology-oncology and their ability to act as an immune effector cells with their cytotoxicity in immunology seem to have opened a new era in MC research. We are currently testing in our laboratory the hypothesis that MC can play a role in the control of the disease process in aplastic anemia, myelodysplastic syndrome and myeloproliferative disorders originating from hematopoietic stem cell through immune modulation. Anahtar Kelimeler : Mast hücresi, hematoloji, onkoloji, bağışıklık sistemi, mast hücre sitotoksisitesi, mast cell, hematology, oncology, immunology, mast cell-mediated cytotoxicity

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