Ibuprofen and indomethacin given intravenously to newborn infants are a proven treatment for patent ductus arteriosus (PDA). While the intravenous form of ibuprofen is not available in our country, the oral suspension form is widely used for antipyretic treatment in children. The aim of this study was to determine the effect of ibuprofen therapy given for PDA to newborn babies and to compare with the effect of indomethacin treatment, retrospectively. Fiftyseven newborn infants who were followed at Hacettepe University Neonatal Intensive Care Unit and who developed symptomatic PDA during their hospital stay were included in this study. İbuprofen and indomethacin therapies were given as three doses (intravenous administration 0.2 mg/kg/dose for three doses given at 12-hour intervals or oral ibuprofen 10 mg/kg/dose for three doses given at 24-hour intervals). PDA was closed in 9 of 11 infants in the ibuprofen group (81%) and 36 of 46 infants given indomethacin (78%) group. As a result, oral ibuprofen therapy is as effective as indomethacin for the treatment of PDA in newborns. Anahtar Kelimeler : patent duktus arteriozus, ibuprofen, indometazin, yenidoğan, patent ductus arteriosus, indomethacin, ibuprofen, newborn.