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^{Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi Pediatri Uzmanı İletişim: istemihancelik@gmail.com} Maternal immunoglobulin (Ig)-G type blood group antibodies other than Rhesus D (RhD) are an increasingly significant cause of alloimmune hemolytic disease of the newborn (HDN). Anti-e-associated HDN has been reported rarely in the literature, and is mostly responsible for mild anemia and hemolysis. We describe herein the first case report of twin brothers with severe hemolytic anemia and hyperbilirubinemia due to anti-e antibodies that required repeated doses of intravenous immunoglobulin (IVIG) and erythrocyte transfusions. They received a total of 4 g/kg IVIG therapy. One month after discharge they had no hemolysis. In conclusion, isoimmunization due to subgroup incompatibility such as anti-e should be considered in patients with hemolysis, anemia and jaundice. Phototherapy, IVIG and transfusion are the treatment options. Anahtar Kelimeler : yenidoğan izoimmünizasyonu, ikiz, anti-e, IVIG