Çocuk Sağlığı ve Hastalıkları Dergisi
2012 , Vol 55 , Num 3
A child with warfarin resistance: vitamin K epoxide reductase (VKOR) gene mutation
Atatürk Üniversitesi Tıp Fakültesi 1Pediatri Yardımcı Doçenti, 2Tıbbi Biyoloji Yardımcı Doçenti, 3Pediatri Profesörü
venous and arterial thromboembolism because of oral intake and its low
price. However, it has a narrow therapeutic range, a high rate of bleeding
complications, and highly variable dose adjustment between individuals. Dose
adjustment is associated with age, gender, weight, height, body surface area,
and CYP2C9 and VKORC1 genetic polymorphisms. We report a patient with
heterozygous VKORC1 gene mutation who failed to reach a therapeutic level
of international normalized ratio (INR) with warfarin therapy.
Anahtar Kelimeler :
varfarin direnci, VKORC1 gen polimorfizmi.