Experience with intravenous ascorbic acid treatment in prilocaine-induced methemoglobinemia is limited. In this report we present our experience about intravenous ascorbic acid treatment in two cases with prilocaine-induced toxic methemoglobinemia. A 25-day-old male newborn and an eight-month-old male infant were admitted to the Emergency Unit with nephrostomy and circumcision operations, respectively. Blood methemoglobin levels were 54% and 31%, respectively. Ascorbic acid (300 mg/kg) was applied by intravenous route, and cyanosis had completely resolved at the end of the second hour. In toxic methemoglobinemia, intravenous ascorbic acid may be used if methylene blue is not available. Ascorbic acid is also safe in glucose-6-phosphate dehydrogenasedeficient patients when compared with methylene blue. Anahtar Kelimeler : Methemoglobinemi, prilokain, askorbik asit, bebek, methemoglobinemia, prilocaine, ascorbic acid, infant